High Cholesterol

by Christiane Northrup, M.D.

Currently 40 percent of women older than fifty-five have elevated cholesterol levels. Because this condition is so common, I recommend that midlife women have a baseline lipid profile measuring total cholesterol, triglycerides, LDL, and HDL cholesterol so they know where they stand. Then get the lipid profile repeated at least every five years. If your blood sugar is high, get the test repeated more frequently.

Ask your doctor to give you a copy of your lipid profile so that you can get to know your numbers. It’s very motivating to watch your lipid profile improve every year when you commit to becoming healthier than ever before at midlife.

Though interpretation of lipid profile results will vary from lab to lab, a total cholesterol level as high as 225 to 240 does not necessarily indicate that a woman is at increased risk for heart disease if her HDL cholesterol is also high (45 or above). Because most of the studies of heart disease and blood lipid levels have been done on men, we still don’t know exactly what levels of blood lipids are optimal for women. What we do know is that women can have higher total cholesterol levels than men and not be at increased risk for heart disease.

And we know a healthy diet and adequate exercise can go a long way toward creating healthy blood lipids.

Listen to Your Body

The following blood lipid levels are optimal; values outside of these ranges indicate cholesterol problems:

  • Total Cholesterol: Below 200. (Note: If your cholesterol is slightly higher than 200, don’t worry about it if your HDL is sufficiently high.)
  • HDL (High-Density Lipoprotein): HDL—the “good” choles-terol—should be 45 or higher; 67 or above is ideal. Low HDL cholesterol has been shown to be a more potent risk factor in women than it is in men. Women with low levels of this cholesterol subtype (a reading of 35 or less) have a sevenfold increase in heart disease risk compared to those whose HDL levels are normal. Low HDL is one of the first indicators of insulin resistance.
  • LDL (Low-Density Lipoprotein): LDL—the “bad” cholesterol— should be 130 or below. LDL undergoes free-radical damage and forms plaques in the arteries. It rises after menopause in many women, a fact that was the basis for promoting estrogen replacement, which decreases LDL levels. If your LDL is greater than 150 mg/dl (some doctors use even lower numbers), you’re considered at high risk for coronary artery disease. Note: The level of LDL cholesterol that is considered “normal” has been continually reduced over the years, largely because of the behind-the-scenes influence of the pharmaceutical industry, which supplies the majority of research grants to academic medicine. The American Heart Association’s 2004 recommendations for “normal” LDL were lowered to 70, which I consider ridiculous.
  • Triglycerides: This number should be 150 or lower. Triglycerides are an independent risk factor for women. An ideal triglyceride level for a woman is around 75. A woman with a triglyceride level of greater than 200 has a 14 percent risk of developing coronary artery disease. High triglycerides are associated with toxic abdominal fat and glycemic stress in part because the liver, as well as other areas of the body, stores excess blood sugar as triglycerides.
  • Relationship of Total Cholesterol to HDL: Divide your total cholesterol by your HDL cholesterol. If the resulting number is 4 or less, you are at low risk, regardless what your total cholesterol number is. This ratio is a much better predictor of risk than simply your total cholesterol number. Remember that neither type of cholesterol is inherently bad or good—both are necessary for good health and they need to be balanced in the body.

What Causes This

See Heart Disease.

Healing Alternatives

I am very concerned about the overuse of statin drugs (such as Lipitor, Crestor, Zocor, etc.), which are being prescribed to millions of women to lower LDL cholesterol levels. High LDL cholesterol is not a disease, and simply lowering LDL cholesterol will not prevent heart disease—at least half of all people who get heart disease don’t even have high cholesterol! Despite all the hype about statins, many large studies failed to show any benefit in reducing overall number of deaths.

In the largest study in the world to use Lipitor (the ALLHAT clinical trial, announced in 2002), the subjects in the group who took Lipitor did, in fact, lower their LDL cholesterol significantly compared to the control group, but there was no reduction in death rate from heart attack. Several other studies yielded similar results, and a 2003 meta-analysis of forty-four clinical trials involving 9,500 patients found that the death rate for those taking statins was identical to those taking no drugs. Results also showed that 65 percent of those taking statins experienced adverse side effects serious enough to cause many to withdraw from the study.

The serious side effects resulting from statins include muscle weakness and fatigue, liver damage, brain and nerve damage and depression. Statins may also promote cancer and even heart disease! This is because of the way they work. Statin drugs block cholesterol production by inhibiting the enzyme HMG-Co-A reductase, but in so doing, statins also block production of two vital nutrients–coenzyme Q10 and substances called dilochols, both of which are absolutely essential for proper cell health.

Dilochols direct proteins to the areas of the cells that need repair. Without them, the cells can’t carry out their genetic programming for cellular functioning and restoration. Statins therefore wreak potential havoc with cellular repair. Coenzyme Q10 is necessary for producing energy in the form of ATP in the part of the cell known as the mitochondria. ATP carries energy for cellular function much like gasoline powers the engine of a car. Without it, nothing can run. The heart, in particular, requires an enormous amount of energy and CoQ10 to function efficiently. CoQ10 is also necessary for the vital role played by cell membranes (the actual “brain” of the cell) and also for the formation of collagen and elastin that make up the connective tissue in skin, muscles, and blood vessel walls. Because every cell in the body requires coenzyme Q10 to function properly, depletion of this enzyme from statin drugs causes problems throughout the entire body.

Spiritual and Holistic Options

Dietary change and a good supplement program can lower cholesterol significantly and quickly (getting regular exercise and stopping smoking also helps, as well). If you cannot or will not institute lifestyle improvements, at least take omega-3 supplements (such as ground flaxseed, either in capsule form or one-quarter cup of fresh ground flax seeds eaten three to seven days per week and mixed with soup, yogurt, or other foods) and consider taking garlic, which has antioxidant properties. (Either lightly cook fresh garlic, or take a garlic supplement with A 10 mg of alliin, or a total allicin potential of 4,000 mcg).

Other helpful supplements include the tocotrienols (50 mg per day daily for a month, and then lower the dose to about 30 mg–two capsules per day–thereafter) and policosanol (20 mg/day). Castano1 For more helpful supplements, see the Hypertension section.

Also add soy to your diet. The American Heart Association officially recommended a daily diet containing soy-based foods after 38 studies found soy protein reduced total cholesterol and LDL. Soy also raises HDL and lowers triglycerides. Erdman2 Consuming 50 grams of soy protein daily can lower LDL cholesterol by as much as eight percent.

Learn More — Additional Resources

  • The Wisdom of Menopause, by Christiane Northrup, M.D., Chapter 14, “Living with Heart, Passion, and Joy: How to Listen to and Love Your Midlife Heart.”

References

  1. Castano, G., Mas, R., Fernandez, L., Ilnait, J., Gamez, R., & Alvarez, E. (2001). Effect of policosanol 20 versus 40 mg/day in the treatment of patients with type II hypercholesterolemia: A 6-month double-blind study. Int. J. Clin. Pharmacol. Res., 21 (1), 43–57; Mirkin, A., Mas, R., Martinto, M., Boccanera, R., Robertis, A., Poudes, R., Fuster, A., Lastreto, E., Yanez, M., Irico, G., McCook, B., & Farre, A. (2001). Efficacy and tolerability of policosanol in hypercholesterolemic postmenopausal women. Int. J. Clin. Pharmacol. Res., 21 (1), 31–41; Qureshi, A. A., et al. (1997). Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters or hypercholesterolemic humans. Nutr. Biochem., 8, 290–298; Torres, O., Agramonte, A.J., Illnait, J., Mas Ferreiro, R., Fernandez, L., & Fernandez, J.C. (1995). Treatment of hypercholesterolemia in NIDDM with policosanol. Diabetes Care, 18 (3), 393–397.
  2. Erdman, J. W. (2000). Soy protein and cardiovascular disease: A statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation, 102 (20), 2555–2559. http://circ.ahajournals.org/cgi/content/full/102/20/2555; Anderson, J. W., et al. (August 3, 1995). Meta-analysis of the effects of soy protein intake on serum lipids. New England J. Medicine, 333 (5), 276–282; Food and Drug Administration, U.S. Department of Health and Human Services, 1999. FDA Talk Paper: FDA approves new health claim for soy protein and coronary heart disease: T99-48, October 20, 1999; Jiang, H. (2001). American Heart Association meeting, San Antonio, TX, 2001. Tulane University School of Public Health.
Last Updated: October 18, 2006

Christiane Northrup, M.D.

Christiane Northrup, M.D.

Christiane Northrup, M.D., is a visionary pioneer and a leading authority in the field of women’s health and wellness. Recognizing the unity of body, mind, and spirit, she empowers women to trust their inner wisdom, their connection with Source, and their ability to truly flourish.

Comments

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  1. Marcy
    1 year ago

    Thank you for the valuable information. My question is do the supplements you recommend apply to men as well? My husband and I are looking for a natural supplement to lower LDL cholesterol.

  2. Janis
    2 years ago

    Hello – hoping to get clarity on which is preferrably – tocotrienols derived from annatto (sp?) or palm? I read in your book this is a “must” and I find conflicting data on which is preferrably; palm being touted as more effective in blocking cholesteral created in liver and annatto as the more systemic.

    I so appreiate your recommended dosage and any other information you can post to give me some starting point for further research and clarity.

    Thank you.

  3. susan turner
    3 years ago

    I don’t have a comment, but a question. There is a co-worker that has been on statins for three years and is showing severe side effects. His doctor took him off the statin he was using and it shows he has liver damage. Now he’s on another pill and was told to go to a GI specialist. The information you give for women would be good for men too, wouldn’t it. It doesn’t make sense that it wouldn’t.

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